hypertensive rats — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3474	RO 46-8443		Endothelin Receptor
	RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.		Endothelin Receptor
T5329	Trandolapril		Angiotensin-converting Enzyme (ACE)
	Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.		Angiotensin-converting Enzyme (ACE)
T3046	BMY 7378 dihydrochloride	BMY7378 HCl	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	BMY 7378 dihydrochloride (BMY7378 HCl) , α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T23044	N,N'-Dicyclohexylurea	DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582	Epoxide Hydrolase
	N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor.		Epoxide Hydrolase
T16329	Nitroflurbiprofen	NO-flurbiprofen,Nitroxybutyl flurbiprofen,HCT 1206	COX
	Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.		COX
T14942	CGP48369		RAAS
	CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats.		RAAS
T12596	(4E)-SUN9221		5-HT Receptor , Adrenergic Receptor
	(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist that shows antihypertensive and antiplatelet aggregation activity in hypertensive rats.		5-HT Receptor , Adrenergic Receptor
T36506	Tempone	4-Oxo-tempo
	Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats.
T28482	Firibastat	QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150	Aminopeptidase
	Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively...		Aminopeptidase
T27743	KRH-594 free acid	WK14922K,WK-1492,WK-14922K,WK1492
	KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-pron...
TN2990	3alpha-dihydrocadambine		Others
	3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats.		Others
T71396	FCE-24379
	FCE-24379 is a selective antagonist of vascular serotonin receptors that has been shown to lowers blood pressure in hypertensive rats.
T28039	Milfasartan	LR-B081,LRB-081,LR-B-081,LRB 081,LR-B 081
	Milfasartan is a potent, selective antagonist of AT1 receptor with oral activity. It markedly lowers the blood-pressure in conscious renal and spontaneously hypertensive rats.
T27306	Fasidotril	BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137
	Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in pati...
T38424	(R)-Fadrozole	FAD286,(R)-CGS 16949A free base,(R)-Fadrozole
	(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in sp...
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapr...
TP1892	γ1-MSH
	Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exh...
T79267	Antihypertensive agent 3
	Antihypertensive agent 3 (compound 4a), an angiotensin II receptor 1 antagonist, demonstrates antihypertensive activity in spontaneously hypertensive rats (SHRs) [1].
T63452	Benidipine
	Benidipine is a potent, orally active calcium channel antagonist. benidipine increases endothelial nitric oxide synthase activity and improves coronary circulation in hypertensive rats. benidipine resists apoptosis in is...
T36207	Methylspinazarin
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxyl...